Ann-ShynChiang
T.H.Hseu
Jya-Wei Cheng
Haimei Huang
J.L.Yang
Y.K. Lai
Thomas S. Tan
Suh-Chin Wu
Horng-Dar Wang
Tzu-Kang Sang
 
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Ann-Shyn Chiang
江安世教授

Professor & Director
Ph.D., RutgersUniversity, 1990

Brain research ;
Confocal imaging;
Nanobiotechnology
email : aschiang@life.nthu.edu.tw
phone (886) 3-574-2760or (886) 3-5731185 
fax (886) 3-5717237
 
 
Enter Brain Research Center
第51屆教育部學術獎頒獎典禮代表致詞
 
  Research Interest: 

Genes, Circuits & Behavior

We are using molecular imaging techniques in Drosophila aiming to understand the genetic and neural basis of brain functions. Two main approaches are taken: (i) to construct a wiring diagram of the entire brain; and (ii) to understand computation in specific circuits for innate as well as learned behaviors.

Wiring diagram. We have generated a standard Drosophila brain for archiving and analysis of individual neurons. We are trying to construct (i) a circuitry map showing connections among different neuropilar regions; and (ii) a map of synaptic connectivity among olfactory neurons.

Brain functions. We focus on understanding circuits and genes involving in the computation process for olfactory, auditory, gustatory, sleep, courtship, fighting, aging, fear, and learned behaviors.

Honor :

  • 行政院96年度傑出科技貢獻獎
  • 2007 傑出人才發展基金會96年度第一期傑出人才講座
  • 2007 第42屆中山學術著作獎
  • 2007 中興大學傑出校友
  • 2007 清華大學96年度清華講座
  • 2007 第51屆教育部學術獎
  • 2005 Outstanding Research Award, National Science Council , Taiwan
  • 1992-2004 Best Research Award (10 times), National Science Council, Taiwan
  • 1990 First place in the Student Paper Competition, Eastern Branch of Entomological Society of America 62nd Annual Meeting, Baltimore , MD. , U.S.A.
  • 1987-1990 Thomas J. Headlee Fellowship, Department of Entomology, Rutgers University , U.S.A.
  • 1989 Radclyffe B. Roberts Scholarship, Department of Entomology, Rutgers University , U.S.A.

Selected Publications : 

  1. Wu CL, Xia S, Fu TF, Wang H, Chen YH, Leong D, Chiang AS*, Tully T*. Specific requirement of NMDA receptors for long-term memory consolidation in Drosophila ellipsoid body. Nature Neuroscience (Advance Online Publication 10.1038/nn2005) (IF: 15.456) <Link>
  2. Lin HH, Jason Lai SY, Chin AL, Chen YC, Chiang AS (2007) A Map of Olfactory Representation in the Drosophila Mushroom Body. Cell 128, 1205-1218. (IF: 29.431) <Link>
  3. Zhu S, Lin S, Kao CF, Awasaki T, Chiang AS, Lee T (2006) Gradients of the Drosophila chinmo BTB-zinc finger protein govern neuronal temporal identity. Cell 127, 409-422. (IF: 29.431) <Link>
  4. Agrawal N, Pallos J, Slepko N, Apostol BL, Bodai L, Chang LW, Chiang AS, Thompson LM, Marsh JL (2005) Identification of combinatorial drug regimens for treatment of Huntington's disease using Drosophila. Proc. Natl. Acad. Sci. USA 102, 3777-81. (IF: 10.23; Ranking: 6.3%) <Link>
  5. Xia S, Miyashita T, Fu TF, Lin WY, Wu CL, Pyzocha L, Lin IR, Saitoe M, Tully T, Chiang AS (2005) NMDA receptors mediate olfactory learning and memory in Drosophila. Curr. Biol. 15, 603-615. (IF: 11.91) <Link>
  6. Agrawal N, Pallos J, Slepko N, Apostol BL, Bodai L, Chang LW, Chiang AS, Thompson LM, Marsh JL (2005) Identification of combinatorial drug regimens for treatment of Huntington’s disease using Drosophila Proc. Natl. Acad. Sci. USA 102, 3777-81 (IF: 10.272) <Link>
  7. ijima K, Liu HP, Chiang AS , Konsolaki M, Zhong Y (2004) A Drosophila model of Alzheimer's disease: dissecting the pathological roles of Ab42 and Ab40. Proc. Natl. Acad. Sci . USA 101, 6623-6628. (IF: 10.272) <Link>
  8. Mignone J, Kukekov V, Chiang AS , Steindler D, Enikolopov G (2004) Neural stem and progenitor cells in nestin-GFP transgenic mice. J. Comp. Neurol. 469, 311-24 (IF: 3.672)
  9. Tamura T, Chiang AS, Ito N, Liu HP, Horiuchi J, Tully T, Saitoe M (2003) Aging specifically impairs amnesiac-dependent memory in Drosophila . Neuron 40, 1-20. (IF: 15.30) <Link>
  10. Zhu S, Chiang AS , Lee T (2003) Development of the Drosophila mushroom bodies: elaboration, remodeling, and spatial organization of dendrites in the calyx. Development 130, 2603--2610. (IF: 7.88) <Link>
  11. Wang Y, Chiang AS, Xia S, Kitamoto T, Tully T, Zhong Y (2003) Blockade of neurotransmission in Drosophila mushroom bodies impairs odor attraction, but not repulsion. Curr . Biol. 13, 1900-1904. (IF: 11.91) <Link>
  12. Dubnau J, Chiang AS, Grady L, Barditch J, Gossweiler S, McNeil J, Smith P, Buldoc F, Scott R, Certa U, Broger C, Tully T (2003) The staufen / pumilio pathway is involved in Drosophila long-term memory. Curr . Biol. 13, 286-296. (cover story) (IF: 11.91) <Link>
  13. Liu YC , Chiang AS * (2003) High-resolution confocal imaging and 3-D rendering. Methods 30, 86-93. (IF: 3.622)
  14. Dubnau J, Chiang AS , Tully T. (2003) Neural substrates of memory: From synapse to system. J. Neurobiol. 54, 238-253. (IF: 3.145)
  15. Chiang AS *, Lin WY, Liu HP, Pszczolkowski MA, Fu TF, Chiu SL, Holbrook GL (2002) Insect NMDA receptors mediate juvenile hormone biosynthesis. Proc. Natl. Acad. Sci . USA 99, 37-42. (IF: 10.7) <Link>
  16. Malaterre J, Strambi C, Chiang AS , Aouane A, Strambi A, Cayre M (2002) Development of cricket mushroom bodies. J. Comp. Neurol. 452, 215-227. (cover story) (IF: 3.672)
  17. Chiang AS *, Liu YC, Chiu SL, Hu SH, Huang CY, Hsieh CH (2001) Three-dimensional mapping of brain neuropils in the cockroach, Diploptera punctata. J. Comp. Neurol. 440, 1-11. (IF: 3.672)

International invited talks :

  • 2007/3/12 A Pilot Platform for Archiving 3D Images of the Drosophila Olfactory Circuitry. Janelia Farm--Howard Hughes Medical Institute, Virginia, USA. (Plenary talk)
  • 2006/07/05 Deconstructing Drosophila Brain Circuits. The Department of Molecular, Cellular and Developmental Biology, Yale University , New Haven , USA
  • 2006/06/28 Deconstructing Drosophila Brain Circuits. Cold Spring Harbor Laboratory , NY , USA
  • 2005 Mapping Memory Circuits in the Drosophila Brain. Molecular Basis of Aging and Neuronal Disorder, Ilsong Institute of Life Science, Hallym University, Anyang, Korea
  • 2005 Mapping Memory Circuits in the Drosophila Brain. Frontiers in Cellular Neuroimaging, RIKEN Brain Science Institute, Wako-shi, Saitama , Japan
  • 2005 Mapping Memory Circuits in the Drosophila Brain. Seminar in the Tokyo Metropolitan Institute for Neuroscience, Fuchu , Tokyo , Japan
  • 2005 Mapping Memory Circuits in the Drosophila Brain, Kunmin Institute of Zoology, Chinese Academy of Sciences, Kunmin, China
  • 2005 Mapping Memory Circuits in the Drosophila Brain, Institute of Neuroscience, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
  • 2004 Mapping Candidate Memory Circuits in the Brain. Cold Spring Harbor Laboratory, USA.
  • 2004 High-resolution confocal imaging of Drosophila brain circuits. 14th International Congress on Photobiology. Jeju, Korea
  • 2004 Symposium on Neural Plasticity, Development and Repair. University of Hong Kong, Hong Kong.
  • 2003 Fly Brain Neurogenomics: Postdoctoral Research Possibilities in Taiwan. Department of Bioscience and Biotechnology, Tsinghua University, Beijing, China.
  • 2002 Bioinformatics Beyond Sequence: Memory Circuits and Brain Database. Institute of Neuroscience, Department of Bioscience and Biotechnology, Tsinghua University, Beijing, China.
  • 2002 Visions from CSHL: High-resolution Mapping of Memory Circuits. Cold Spring Harbor Laboratory, USA.
  • 2002 High-resolution Confocal Imaging of Olfactory Memory Circuits in the Drosophila Brain. Department of Cell & Structural Biology, University of Illinois. USA.
  • 2002 High-resolution Confocal Imaging of Olfactory Memory Circuits in the Drosophila Brain. Department of Entomology, Department of Entomology Genetics, North Carolina University. USA

Patent :

  • Aqueous Tissue Clearing Solution. USA Patent No: US 6472216 B1. Taiwan Patent No: 206390. United Kingdom Patent No: GB237757. France Patent No: 2830323
  • 3D Montage. Taiwan Patent No: 206631. ( USA and China patent pending)
  • Bio-Expression System and the Method of the Same ( USA and Taiwan patent pending)
 
 
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