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Research Interest:
My research interests focus on how gene expression changes
affect phenotypes in a living organism, especially stress
resistance and life extension. Longevity organisms usually
possess better resistance to a variety of stresses. To
better and efficiently identify longevity genes, I developed
a multiple stress strategy to isolate genes or mutants
in response to oxidative, starvation, and heat stresses.
By using the multiple stress strategy on both forward and
reverse genetic screens, I have isolated several mutants
or genes to provide longevity and stress resistance in Drosophila
melanogaster . Perspective study is to further identify
and characterize the genes and mutants from the screens.
The goal is to find the genes and eventually delineate
pathways involved in longevity and stress resistance. A
drug screen by the multiple stress strategy will be pursued
to look for the fountain of youth. The study is valuable
for the identification of targets and the development of
therapeutic agents for treatments of stress and age related
diseases, like cardiovascular disease, neurodegeneration,
and cancer. It will help to find out not only how to live
longer but also vigorously.
Selected Publications:
- Wang, H.-D., Kazemi-Esfarjani, P., and Benzer
S. (2004). Multiple-stress analysis for isolation of Drosophila longevity
genes. Proc. Natl. Acad. Sci. USA 101:12610-12615.
- Johnson, S.S., Mandavia N., Wang, H.-D., and Johnson
D.L. (2000). Transcriptional Regulation of the TATA-Binding Protein
by Ras Cellular Signaling. Mol. Cell. Biol.20 : 5000-5009.
- Wang, H.-D., Trivedi, A., and Johnson D.L. (1998).
Regulation of RNA Polymerase I-Dependent Promoter by the Hepatitis
B Virus X Protein via Activated Ras and TATA-binding Protein.
Mol. Cell. Biol. 18 : 7086-7094.
- Wang, H.-D., Trivedi, A., and Johnson D.L. (1997).
Hepatitis B Virus X Protein induces RNA Polymerase III-dependent
Gene transcription and Increases Cellular TATA-Binding Protein
by Activating the Ras Signaling Pathway. Mol. Cell. Biol. 17
: 6838-6846.
- Wang, H.-D., Yuh, C.-H., Dang, C.V., and Johnson
D.L. (1995). The Hepatitis B Virus X Protein Increases the Cellular
Level of TATA-binding Protein which Mediates Transactivation
of RNA Polymerase III Genes. Mol. Cell. Biol. 15 : 6720-6728.
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