Professor
Ph.D., Michigan State University

Molecular Biology

Research Interest: 
Molecular Biology

Selected Publications: 

1. Ko JC, Wang YT, and Yang JL. Dual and opposing roles of ERK in regulating G1 and S-G2/M delays in A549 cells caused by hyperoxia. Exp Cell Res 297: 472-483. (2004)
   
   
2. Lin YW, Chuang SM, Yang JL. ERK1/2 achieves sustained activation by stimulation of MAPK phosphatase-1 degradation through ubiquitin-proteasome pathway. J Biol Chem 278, 21534-21541 (2003)
   
   
3. Lin YW, Chuang SM, Yang JL. Persistent activation of ERK1/2 by lead acetate increases nucleotide excision repair synthesis and confers anti-cytotoxicity and anti-mutagenicity. Carcinogenesis 24, 53-61 (2003)
   
   
4. Chuang SM, Wang IC, Hwua YS, Yang JL. Short-term depletion of catalase suppresses cadmium-elicited c-Jun N-terminal kinase activation and apoptosis: role of protein phosphatases. Carcinogenesis 24, 7-15 (2003)
   
   
5. Yang JL, Chuang SM. Comparison of roles of three mitogen-activated protein kinases induced by chromium(VI) and cadmium in non-small-cell lung carcinoma cells. Mol Cell Biochem 222, 85-95 (2001)
   
   
6. Chao JI, Yang JL, Alteration of cadmium-induced mutational spectrum by catalase depletion in Chinese hamster ovary-K1 cells. Mutat. Res. 498, 7-18 (2001)
   
   
7. Chao JI, Yang JL Opposite roles of ERK and p38 mitogen-activated protein kinases in cadmium-induced genotoxicity and mitotic arrest. Chem. Res. Toxicol. 14, 1193-1202 (2001)
   
   
8. Chuang SM, Liou GY, Yang JL Activation of JNK, p38 and ERK mitogen-activated protein kinases by chromium(VI) is mediated through oxidative stress but does not affect cytotoxicity. Carcinogenesis 21, 1491-1500 (2000)
   
   
9. Chuang SM, Wang IC, Yang JL.. Roles of JNK, p38 and ERK mitogen-activated protein kinases in the growth inhibition and apoptosis induced by cadmium. Carcinogenesis 21, 1423-1432 (2000)
   
   
10. Tsou TC, Lai HJ, Yang JL. Effects of mannitol or catalase on the generation of reactive oxygen species leading to DNA damage by chromium(VI) reduction with ascorbate. Chem. Res. Toxicol. 12, 1002-1009 (1999)
    
    
11. Yang JL, Wang LC, Chang CY, Liu TY. Singlet oxygen is the major species participating in the induction of DNA strand breakage and 8-hydroxydeoxyguanosine adduct by lead acetate. Environ. Mol. Mutagen. 33, 161-168 (1999)