Shiue-Cheng （Tony） TangPersonal data of - Institute of Biotechnology,NTHU

Faculty

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Name	Shiue-Cheng （Tony） Tang
Personal website	http://www.3d-histology.com

Category	Full-Time
Title	Professor
Administrative Affairs	Institute of Biotechnology / Interdisciplinary Program of Life Science / Department of Medical Science
Research expertise	3-D microscopy with optical clearing Enteric neurovascular histology Pancreatic islet histology & biology
Forum	Forum link

Recent Publications
Year	Publication	Author
2019	Shen CN, Goh KS, Huang CR, Chiang TC, Lee CY, Jeng YM, Peng SJ, Chien HJ, Chung MH, Chou YH, Hsieh CC, Kulkarni S, Pasricha PJ, Tien YW, and Tang SC. Lymphatic vessel remodeling and invasion in pancreatic cancer progression. EBioMedicine, 2019. Accepted,	Shiue-Cheng （Tony） Tang
2019	Chien HJ, Chiang TC, Peng SJ, Chung MH, Chou YH, Lee CY, Jeng YM, Tien YW, and Tang SC*. Human pancreatic afferent and efferent nerves: mapping and 3-D illustration of exocrine, endocrine, and adipose innervation. American Journal of Physiology - Gastrointestinal and Liver Physiology, 2019. Accepted,	Shiue-Cheng （Tony） Tang
2018	Tang SC, Shen CN, Lin PY, Peng SJ, Chien HJ, Chou YH, Chamberlain CE, and Pasricha PJ. Pancreatic neuro-insular network in young mice revealed by 3-D panoramic histology. Diabetologia. 61:158-167, 2018,	Shiue-Cheng （Tony） Tang
2018	Tang SC*, Baeyens L, Shen CN, Peng SJ, Chien HJ, Scheel DW, Chamberlain CE, and German MS. Human pancreatic neuro-insular network in health and fatty infiltration. Diabetologia, 61:168-181, 2018,	Shiue-Cheng （Tony） Tang
2018	Tang SC, Jessup CF, and Campbell-Thompson M*. The role of accessory cells in islet homeostasis. Current Diabetes Reports. 18(11):117, 2018. Review,	Shiue-Cheng （Tony） Tang
2018	Peng SJ and Tang SC*. Nature Reviews Endocrinology, Cover image 2019 Jan-Dec, all twelve issues: Peri-islet vasodilation and lymphocytic infiltration in experimental type 1 diabetes mellitus. Winner of 2018 Nature Reviews cover image competition (https://www.nature.com/nrendo/volumes/15/issues/1),	Shiue-Cheng （Tony） Tang
2017	Tang SC, Peng SJ, Baeyens L and German MS. Nature Reviews Endocrinology, Cover image 2017 Jan-Dec, all twelve issues: Human pancreatic microenvironment in type 2 diabetes mellitus. http://www.nature.com/nrendo/journal/v13/n1/index.html,	Shiue-Cheng （Tony） Tang
2017	Kulkarni S, Micci MA, Leser J, Shin C, Tang SC, Fu YY, Liu L, Li Q, Saha M, Li C, Enikolopov G, Becker L, Rakhilin N, Anderson M, Shen X, Dong X, Butte MJ, Song H, Southard-Smith EM, Kapur RP, Bogunovic M, Pasricha PJ. Adult enteric nervous system in health is maintained by a dynamic balance between neuronal apoptosis and neurogenesis. Proc Natl Acad Sci USA,114: E3709-E3718, 2017. (Contribution: application of 3-D histology to investigate enteric nervous system),	Shiue-Cheng （Tony） Tang
2016	Chien HJ, Peng SJ, Hua TE, Kuo CH, Juang JH, and Tang SC. 3-D imaging of islets in obesity: formation of the islet-duct complex and neurovascular remodeling in young hyperphagic mice. International Journal of Obesity, 40: 685-697, 2016 (5 of 81 in NUTRITION & DIETETICS),	Shiue-Cheng （Tony） Tang
2016	Lin PY, Peng SJ, Shen CN, Pasricha PJ, and Tang SC. PanIN-associated pericyte, glial, and islet remodeling in mice revealed by 3-D pancreatic duct lesion histology. American Journal of Physiology - Gastrointestinal and Liver Physiology, 311: G412–G422, 2016,	Shiue-Cheng （Tony） Tang
2015	Liu YA, Chung YC, Shen MY, Pan ST, Kuo CW, Peng SJ, Pasricha PJ, and Tang SC. Perivascular interstitial cells of Cajal in human colon. Cellular and Molecular Gastroenterology and Hepatology, 1(1):102-119, 2015. American Gastroenterological Association journal,	Shiue-Cheng （Tony） Tang
2015	Peng SJ and Tang SC. Nature Reviews Nephrology, Cover image 2015 Jan-Dec, all twelve issues: Projection of mouse renal pericytes and their association with glomeruli. http://www.nature.com/nrneph/journal/v11/n12/index.html,	Shiue-Cheng （Tony） Tang
2015	Juang JH, Kuo CH, Peng SJ, and Tang SC. 3-D imaging reveals participation of donor islet Schwann cells and pericytes in islet transplantation and graft neurovascular regeneration. EBioMedicine, 2:109-119, 2015. Cover image of February issue,	Shiue-Cheng （Tony） Tang
2014	Hsu CT and Tang SC. Nature Reviews Endocrinology, Cover image 2014 Jan-Dec, all twelve issues: Mouse islet Schwann cell network. http://www.nature.com/nrendo/journal/v10/n1/index.html,	Shiue-Cheng （Tony） Tang
2014	Juang JH, Peng SJ, Kuo CH, and Tang SC. 3D islet graft histology: panoramic imaging of neural plasticity in sympathetic reinnervation of transplanted islets under the kidney capsule. American Journal of Physiology - Endocrinology and Metabolism, 306:E559-E570, 2014,	Shiue-Cheng （Tony） Tang
2014	Tang SC*, Peng SJ, and Chien HJ. Imaging of the islet neural network. Diabetes, Obesity and Metabolism. Review, 2014. (IF: 6.715),	Shiue-Cheng （Tony） Tang
2013	Fu YY, Peng SJ, Lin HY, Pasricha PJ, and Tang SC. 3-D imaging and illustration of mouse intestinal neurovascular complex. American Journal of Physiology - Gastrointestinal and Liver Physiology. 304:G1-G11, 2013 (Cover image),	Shiue-Cheng （Tony） Tang
2013	Liu YA, Chung YC, Pan ST, Shen MY, Hou YC, Peng SJ, Pasricha PJ, and Tang SC. 3-D imaging, illustration, and quantitation of enteric glial network in transparent human colon mucosa. Neurogastroenterology & Motility. 25:e324-338, 2013,	Shiue-Cheng （Tony） Tang
2013	Tang SC*, Chiu YC, Hsu CT, Peng SJ, and Fu YY. Plasticity of Schwann cells and pericytes in response to islet injury in mice. Diabetologia. 56:2424-2434, 2013 (Cover image of November issue) ,	Shiue-Cheng （Tony） Tang
2013	Hua TE, Yang TL, Yang WC, Liu KJ, and Tang SC. 3-D neurohistology of transparent tongue in health and injury with optical clearing. Frontiers in Neuroanatomy, 7:36 (10 pages), 2013,	Shiue-Cheng （Tony） Tang
2012	Liu YA, Chung YC, Pan ST, Hou YC, Peng SJ, Pasricha PJ, and Tang SC. 3-D illustration of network orientations of interstitial cells of Cajal subgroups in human colon as revealed by deep-tissue imaging with optical clearing. American Journal of Physiology - Gastrointestinal and Liver Physiology. 302:G1099-G1110, 2012, selected as featured article on the May 15 issue: "3-D illustration of ICC network orientations" ,	Shiue-Cheng （Tony） Tang
2012	Chiu YC, Hua TE, Fu YY, Pasricha PJ, and Tang SC. 3-D imaging and illustration of the perfusive mouse islet sympathetic innervation and its remodelling in injury. Diabetologia. 55:3252-3261, 2012. Diabetologia commissioned a commentary “Islet nerves in focus – defining their neurobiological and clinical role” 55:3152-3154, 2012 http://www.ncbi.nlm.nih.gov/pubmed/23001378 to accompany this paper. Also, this article is selected as ‘Up Front’ to be included at the front of the December 2012 issue,	Shiue-Cheng （Tony） Tang
2011	Liu YA, Chen Y, Chiang AS, Peng JS, Pasricha PJ, and Tang SC. Optical clearing improves the imaging depth and signal-to-noise ratio for digital analysis and 3-dimensional projection of the human enteric nervous system. Neurogastroenterology & Motility. 23:e446-457, 2011. This article is highlighted by Nature Reviews Gastroenterology & Hepatology 8, 600: Improving 3D imaging of the enteric nervous system,	Shiue-Cheng （Tony） Tang
2011	Tseng SJ, Chen ZH, and Tang SC. Application of heparinized cellulose matrices for substrate-mediated bFGF peptide and transgene delivery to stimulate cellular proliferation. Cellulose. 18: p95-104, 2011,	Shiue-Cheng （Tony） Tang
2010	Fu YY and Tang SC. At the movies: 3-dimensional technology and gastrointestinal histology. Gastroenterology, 139(4): p1100-1105, 2010,	Shiue-Cheng （Tony） Tang
2010	Tang SC, Fu YY, Lo WF, Hua TE, and Tuan HY. Vascular labeling of luminescent gold nanorods enables 3-D microscopy of mouse intestinal capillaries. ACS Nano, 4(10):6278-84, 2010,	Shiue-Cheng （Tony） Tang
2010	Fu YY and Tang SC. Optical clearing facilitates integrated 3D visualization of mouse ileal microstructure and vascular network with high definition. Microvascular Research, 80(3):512-21, 2010,	Shiue-Cheng （Tony） Tang
2010	Fu YY, Lu CH, Lin CW, Juang JH, Enikolopov G, Sibley E, Chiang AS, Tang SC. Three-dimensional optical method for integrated visualization of mouse islet microstructure and vascular network with subcellular-level resolution. Journal of Biomedical Optics. 15(4), Article Number: 046018 (9 pages), 2010,	Shiue-Cheng （Tony） Tang
2009	Fu YY, Lin CW, Enikolopov G, Sibley E, Chiang AS, and Tang SC. Microtome-free 3-dimensional confocal imaging method for visualization of mouse intestine with subcellular-level resolution. Gastroenterology. 137(2): p453-465, 2009 ,	Shiue-Cheng （Tony） Tang
2009	Tseng SJ, Lee YH, Chen ZH, Lin HH, Lin CY, and Tang SC. Integration of optical clearing and optical sectioning microscopy for three dimensional imaging of natural biomaterial scaffolds in thin sections. Journal of Biomedical Optics. 14(4), Article Number: 044004 (9 pages), 2009,	Shiue-Cheng （Tony） Tang
2008	Wang ZH, Chien WC, Yue TW and Tang SC. Application of heparinized cellulose affinity membranes in recombinant adeno-associated virus serotype 2 binding and delivery. Journal of Membrane Science. 310: p141-148, 2008,	Shiue-Cheng （Tony） Tang
2008	Chen CA, Lo CK, Lin BL, Sibley E, and Tang SC. Application of doxorubicin-induced rAAV2-p53 gene delivery in combined chemotherapy and gene therapy for hepatocellular carcinoma. Cancer Biology & Therapy. 7(2): p303-309, 2008,	Shiue-Cheng （Tony） Tang
2008	Tseng SJ, Chuang CJ and Tang SC. Electrostatic immobilization of DNA polyplexes on small intestinal submucosa for tissue substrate-mediated transfection. Acta Biomaterialia. 4: p799-807, 2008,	Shiue-Cheng （Tony） Tang
2008	Fu YY, Sibley E, and Tang SC. Transient cytochalasin-D treatment induces apically administrated rAAV2 across tight junctions for transduction of enterocytes. Journal of General Virology. 89: p3304-3308, 2008,	Shiue-Cheng （Tony） Tang
2008	Li H, Shih WH, Shih WY, Chen L, Tseng SJ and Tang SC. Transfection of aqueous CdS quantum dots using polyethylenimine. Nanotechnology. 19, Article Number: 475101 (8 pages), 2008,	Shiue-Cheng （Tony） Tang
2007	Yue TW, Chien WC, Tseng SJ and Tang SC. EDC/NHS-mediated heparinization of small intestinal submucosa for recombinant adeno-associated virus serotype 2 binding and transduction. Biomaterials. 28(14): p2350-2357, 2007,	Shiue-Cheng （Tony） Tang
2007	Tseng SJ and Tang SC. Development of poly(amino ester glycol urethane)/siRNA polyplexes for gene silencing. Bioconjugate Chemistry. 18(5): p1383-1390, 2007,	Shiue-Cheng （Tony） Tang
2007	Tseng SJ and Tang SC. Synthesis and characterization of a novel transfection reagent poly(amino ester glycol urethane). Biomacromolecules. 8(1): p50-58, 2007,	Shiue-Cheng （Tony） Tang

Honors & Awards (outside NTHU)
Year of award	Name of award	Awarded by
9	American Gastroenterological Association (AGA) Fellow, 2017
8	Winner of Nature Reviews Cover Image Competition (Endocrinology 2014, 2017, and 2019; Nephrology 2015)
7	American Diabetes Association, Member, 2012
6	Scientific Paper Award by Far Eastern Y. Z. Hsu Science and Technology Memorial Foundation, Taiwan (category: biomedical technology), 2011
5	Academic Sinica Junior Research Investigator Award (category: life sciences), 2011
4	American Physiological Society, Member, 2011
3	Young Investigator Award, National Science Council, 2009
2	American Gastroenterological Association (AGA), International Affiliate Member, 2005
1	American Gastroenterological Association (AGA), Trainee Member, 2004

Educational background summary
School name	Country	Department	Degree	Starting date
Stanford University School of Medicine	USA	Pediatric Gastroenterology	Postdoctoral Fellow	2004-01 ~ 2004-12
Georgia Institute of Technology	USA	Chemical & Biomolecular Engineering	Ph.D.	1998-09 ~ 2003-12
National Cheng Kung University, Taiwan		Chemical Engineering	M.S.	1992-09 ~ 1994-05
National Cheng Kung University, Taiwan		Chemical Engineering	B.S.	1988-09 ~ 1992-05

Title	Date	Attached file
Research featured in NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY, 2017 Jan. Editorial: covering gastroenterology and hepatology. Lymphatic vessel system in mouse intestine. http://www.nature.com/nrgastro/journal/v14/n1/pdf/nrgastro.2016.188.pdf
Research featured in NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY, 2011 Nov. Neurogastroenterology: Improving 3D imaging of the enteric nervous system. http://www.nature.com/nrgastro/journal/v8/n11/full/nrgastro.2011.167.html

Service organization/unit	Title	Department	Starting date
National Tsing Hua University, Taiwan	Professor	Institute of Biotechnology	2012-02 ~
National Tsing Hua University, Taiwan	Professor	Department of Medical Science	2012-02 ~
National Tsing Hua University, Taiwan	Professor (joint appointment)	Chemical Engineering	2012-02 ~
National Tsing Hua University, Taiwan	Professor	Chemical Engineering	2011-08 ~ 2012-01
National Tsing Hua University, Taiwan	Associate Professor	Chemical Engineering	2008-08 ~ 2011-07
National Tsing Hua University, Taiwan	Assistant Professor	Chemical Engineering	2005-08 ~ 2008-07
Nanyang Technological University, Singapore	Assistant Professor	Chemical & Biomolecular Engineering	2005-01 ~ 2005-07

Institute of Biotechnology,NTHU

Faculty

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