Chuang-Rung Chang Personal data of - Institute of Biotechnology,NTHU

Faculty

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Name	Chuang-Rung Chang
Office Tel.	03-5742776
E-mail
Personal website	https://crclabatnthu.weebly.com/
MSN	https://www.facebook.com/crclabatnthu

Category	Full-Time
Title	Associate Professor
Administrative Affairs	Institute of Biotechnology / Institute of Systems Neuroscience / Interdisciplinary Program of Life Science / Department of Medical Science
Discipline	Cellular and Molecular Biology, Organelle transportation, Epigenetics and Yeast Genetics
Research expertise	Parthenogenesis and mitochondria dynamics/activity, Desiccation tolerance

Recent Publications
Year	Publication	Author
2021	Kuliešienė, N, Žūkienė R, Khroustalyova, G, Chang CR, Rapoport A and Daugelavičius R.,2021,Changes in Energy Status of Saccharomyces cerevisiae Cells during Dehydration and Rehydration.,Microorganisms,9,2,pp444- (SCI)	Chuang-Rung Chang
2020	Chuang KC, Chang CR, Chang SH, Huang SW, Chuang SM, Li ZY, Wang ST, Kao JK, Chen YJ, Shieh JJ.,2020,Imiquimod-induced ROS production disrupts the balance of mitochondrial dynamics and increases mitophagy in skin cancer cells.,J. Dermatol. Sci.,98,3,pp152-162 (SCI)	Chuang-Rung Chang
2019	Kurylenko O, Rozenfelde L, Khroustalyova G, Vasylyshyn R, Ruchala J, Chang CR, Daugelavicius R, Sibirny A, Rapoport A.,2019,Anhydrobiosis in yeasts: glutathione synthesis by yeast Ogataea (Hansenula) polymorphacells after their dehydration-rehydration.,J Biotechnol.,304,pp28-30 (SCI)	Chuang-Rung Chang
2019	Kuo YY, Huo C, Lin CY, Lin HP, Liu JS, Wang WC, Chang CR, Chuu CP.,2019,Caffeic acid phenethyl ester suppresses androgen receptor signaling and stability via inhibition of phosphorylation on Ser81 and Ser213.,Cell Commun Signal.*,17,1,pp100- (SCI)	Chuang-Rung Chang
2019	Chen YC, Cheng TH, Lin WL, Chen CL, Yang WY, Blackstone C, Chang CR.,2019,Srv2 is a pro-fission factor that modulates yeast mitochondrial morphology and respiration by regulating actin assembly.,iScience*,11,pp305-317 (SCI)	Chuang-Rung Chang
2018	Lin CY, Jan YJ, Kuo LK, Wang BJ, Huo C, Jiang SS, Chen SC, Kuo YY, Chang CR, Chuu CP.,2018,Elevation of Androgen Receptor Promotes Prostate Cancer Metastasis via Induction of EMT and Reduction of KAT5.,Cancer Sci.,109,11,pp3564-3574 (SCI)	Chuang-Rung Chang
2018	Kulikova-Borovikovaa D, Khroustalyovaa G, Chang CR, Daugelaviciusc R, Yurkivd M, Ruchalae J, Sibirnyd A, Rapoporta A.,2018,Anhydrobiosis in yeast: Glutathione overproduction improves resistance to dehydration of a recombinant Ogataea (Hansenula) polymorpha strain.,Process Biochem.,71,pp41-44 (SCI)	Chuang-Rung Chang
2016	Chen YJ, Chuang YC, Chuang CN, Cheng YS, Chang CR, Leng CH, and Wang TF. ,2016,S. cerevisiae Mre11 recruits conjugated SUMO moieties to facilitate the assembly and function of the Mre11-Rad50-Xrs2 complex. Epub 2016 Jan 6,Nucleic Acids Res.,44,5,pp2199-2213 (SCI)	Chuang-Rung Chang
2015	Lo MC, Chen MH, Lee WS, Lu CI, Chang CR, Kao SH, Lee HM.,2015,Nε-(carboxymethyl) lysine-induced mitochondrial fission and mitophagy causes decreased insulin secretion from beta cells.,Am J Physiol Endocrinol Metab.,309,10,ppE829-39 (SCI)	Chuang-Rung Chang
2015	Chien L, Chen WK, Liu ST, Chang CR, Kao MC, Chen KW, Chiu SC, Hsu ML, Hsiang IC, Chen YJ, Chen L.,2015,Low-dose ionizing radiation induces mitochondrial fusion and increases expression of mitochondrial complexes I and III in hippocampal neurons.,Oncotarget,6,31,pp30628-39 (SCI)	Chuang-Rung Chang
2015	Kuo YY, Jim WT, Su LC, Chung CJ, Lin CY, Huo C, Tseng JC, Huang SH, Lai CJ, Chen BC, Wang BJ, Chan TM, Lin HP, Chang WW, Chang CR, Chuu CP.,2015,Caffeic acid phenethyl ester is a potential therapeutic agent for oral cancer.,Int. J. Mol. Sci.,16,5,pp10748-10766 (SCI)	Chuang-Rung Chang
2014	Wang IH, Chen HY, Wang YH, Chang KW, Chen YC, Chang CR,2014,Resveratrol Modulates Mitochondria Dynamics in Replicative Senescent Yeast Cells,PLoS One*,9,8,ppe104345- (SCI)	Chuang-Rung Chang
2013	Huang TL, Hsu HC, Chen HC, Lin HC, Chien CY, Fang FM, Huang CC, Chang HW, Chang WN, Huang CR, Tsai NW, Kung CT, Wang HC, Lin WC, Cheng BC, Su YJ, Chang YT, Chang CR, Tan TY, Lu CH. ,2013,Long-term effects on carotid intima-media thickness after radiotherapy in patients with nasopharyngeal carcinoma.,Radiat Oncol*,8,1,pp261- (SCI)	Chuang-Rung Chang
2013	Huang CC, Huang TL, Hsu HC, Chen HC, Lin HC, Chien CY, Fang FM, Chang HW, Tsai NW, Chang WN, Chen SF, Lin TK, Tan TY, Chang CR, Wang HC, Lin WC, Lu CH.,2013,Long-term effects of neck irradiation on cardiovascular autonomic function: A study in nasopharyngeal carcinoma patients after radiotherapy.,Muscle Nerve,47,3,pp344-350 (SCI)	Chuang-Rung Chang
2012	Liu CR, Chang CR, Chern Y, Wang TH, Hsieh WC, Shen WC, Chang CY, Chu IC, Deng N, Cohen SN, Cheng TH.,2012,Spt4 is selectively required for transcription of extended trinucleotide repeats. ,Cell,148,4,pp690-701 (SCI)	Chuang-Rung Chang
2012	Jheng HF, Tsai PJ, Guo SM, Kuo LH, Chang CS, Su IJ, Chang CR, Tsai YS. ,2012,Mitochondrial fission contributes to mitochondrial dysfunction and insulin resistance in skeletal muscle.,Mol Cell Biol.,32,2,pp309-19 (SCI)	Chuang-Rung Chang
2011	Blackstone C, Chang CR,2011,Mitochondria unite to survive,Nat Cell Biol.,13,5,pp521-22 (SCI)	Chuang-Rung Chang
2010	Chang CR, Manlandro CM, Arnoult D, Stadler J, Posey AE, Hill RB, Blackstone C.,2010,A lethal de novo mutation in the middle domain of the dynamin-related GTPase Drp1 impairs higher-order assembly and mitochondrial division.,J Biol Chem.,285,42,pp32494-503 (SCI)	Chuang-Rung Chang
2010	Chang CR, Blackstone C,2010,Dynamic regulation of mitochondrial fission through modification of the dynamin-related protein Drp1,Ann N Y Acad Sci. ,1201,pp34-9 (SCI)	Chuang-Rung Chang
2009	Figueroa-Romero C, Iñiguez-Lluh JA, Stadler J, Chang CR, Arnoult D, Keller PJ, Hong Y, Blackstone C, Feldman EL.,2009,SUMOylation of the mitochondrial fission protein Drp1 occurs at multiple nonconsensus sites within the B domain and is linked to its activity cycle,FASEB J.,23,11,pp3917-27 (SCI)	Chuang-Rung Chang
2008	Cereghetti GM, Stangherlin A, Martins de Brito O, Chang CR, Blackstone C, Bernardi P, Scorrano L. ,2008,Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria. ,Proc Natl Acad Sci U S A.,105,41,pp15803-8 (SCI)	Chuang-Rung Chang
2007	Chang CR, Blackstone C. ,2007,Drp1 phosphorylation and mitochondrial regulation. ,EMBO Rep. ,12,pp1088-9 (SCI)	Chuang-Rung Chang
2007	Chang CR, Blackstone C. ,2007,Cyclic AMP-dependent protein kinase phosphorylation of Drp1 regulates its GTPase activity and mitochondrial morphology. ,J Biol Chem.,282,30,pp21583-7 (SCI)	Chuang-Rung Chang
2005	Chang CR, Wu CS, Hom Y, Gartenberg MR. ,2005,Targeting of cohesin by transcriptionally silent chromatin. ,Genes Dev. ,19,24,pp3031-42 (SCI)	Chuang-Rung Chang
2000	Cheng TH, Chang CR, Joy P, Yablok S, Gartenberg MR. ,2000,Controlling gene expression in yeast by inducible site-specific recombination. ,Nucleic Acids Res.,28,24,ppE108- (SCI)	Chuang-Rung Chang
1999	Ho YS, Lee HM, Chang CR, Lin JK. ,1999,Induction of Bax protein and degradation of lamin A during p53-dependent apoptosis induced by chemotherapeutic agents in human cancer cell lines.,Biochem Pharmacol,57,2,pp143-54 (SCI)	Chuang-Rung Chang

Seminar paper summary
Year	Conference period	Publication	Author
2020	2019/09/12 2019/09/13	Chang-Lin Chen, Jia-Chen Tsai, Wei-Ling Huang, Ying-Hsuan Meng, Ju-Chun Huang, Ying-Chieh Chen, and Chuang-Rung Chang,2020,Mitochondria dynamics and pathogenesis,2019 International Conference on Life Sciences and Technology,Malang, Indonesia,2019/09/12-2019/09/13	Chuang-Rung Chang

Research Interests
Title	Date	Attached file
	2020-03-03	動態的粒線體胞器網路
Mitochondria Dynamics and Pathogenesis	2019-01-12	粒線體融合與分裂動態調控與相關疾病之探討

Honors & Awards (NTHU)
Year of award	Name of award	Awarded by
2020	Mentor Award	National Tsing Hua University
2012	Teaching Award	College of Life Science, National Tsing Hua University
2011	Junior Faculty Research Award	College of Life Science, National Tsing Hua University

Educational background summary
School name	Country	Department	Degree	Starting date
Rutgers University/University of Medicine and Dentistry of New Jersey	U.S.A.	Cellular and Molecular Pharmacology, Graduate School of Biomedical Sciences	Ph. D.	1998-09 ~ 2004-09
Taipei Medical College	R.O.C.	Medical Laboratory Science and Biotechnology	B. S., in Medical Technology	1990-09 ~ 1994-09

Experiences
Service organization/unit	Title	Department	Responsbilities	Starting date
Asian Society for Mitochondrial Research and Medicine			Council Member	2019-10 ~
Taiwan Society for Mitochondrial Research and Medicine			Council Member	2016-01 ~
The Society for Free Radical Research-Taiwan （SFRR-Taiwan）			Council member	2015-10 ~ 2018-10
National Institutes of Health	Postdoctoral Fellow	National Institute of Neurological Disorders and Stroke, NIH		2005-05 ~ 2009-02
University of Medicine and Dentistry of New Jersey	Postdoctoral Fellow	Department of Pharmacology, RWJMS		2004-09 ~ 2005-04

Subject

必修
1. 人體解剖學虛擬實作　
2. 高等分子生物學　
3. 分子與細胞生物學三　
4. 人體生理與解剖學　
選修
1. 生命科學之模式生物　
2. 粒線體，老化與神經元退化特論　
3. 細胞自噬與疾病特論　
4. 酵母菌分子生物學　
5. 書報討論　
6. 胞器的形成與傳輸　
7. 基因修飾與調控　
8. 酵母菌遺傳及基因體學　
9. 高等生物科技學

Institute of Biotechnology,NTHU

Faculty

Subject

標準版RSs 2.x套裝

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